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	<title>Comments on: Swine flu. A family history</title>
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		<title>By: Sergio Stagnaro</title>
		<link>http://biopinionated.com/2009/11/20/swine-flu-a-family-history/#comment-673</link>
		<dc:creator><![CDATA[Sergio Stagnaro]]></dc:creator>
		<pubDate>Wed, 25 Nov 2009 15:26:58 +0000</pubDate>
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		<description><![CDATA[In spite of the fact that there are at least 6 diverse test types in diagnosing flu,showing different sensibility and sensitivity,  I think to the people living in mountains, in little towns, away from laboratores and hospitals, who cannot undergo to such as technological diagnosis. That&#039;s true: thanks to the terrible Flu Pandemic, an enormous number of papers are written on  behalf of mankind!]]></description>
		<content:encoded><![CDATA[<p>In spite of the fact that there are at least 6 diverse test types in diagnosing flu,showing different sensibility and sensitivity,  I think to the people living in mountains, in little towns, away from laboratores and hospitals, who cannot undergo to such as technological diagnosis. That&#8217;s true: thanks to the terrible Flu Pandemic, an enormous number of papers are written on  behalf of mankind!</p>
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		<title>By: sciphu</title>
		<link>http://biopinionated.com/2009/11/20/swine-flu-a-family-history/#comment-672</link>
		<dc:creator><![CDATA[sciphu]]></dc:creator>
		<pubDate>Wed, 25 Nov 2009 13:50:53 +0000</pubDate>
		<guid isPermaLink="false">http://biopinionated.com/?p=1921#comment-672</guid>
		<description><![CDATA[Sergio. Your undocumented statement against a well established diagnostic molecular test is &quot;...can be diagnosed exclusively with sophisticated semeiotics (who’s specificity/sensitivity is about 60%!)&quot;. Your statement is wrong. Given that the samples are taken appropriately, our method (same as used by health agencies around the world) has a very high sensitivity 98-99 % or more, and a specificity of very close to 100 %. Thus, diagnosing this infection is currently not problematic at all, and any further improvements in diagnostics is going to be in the numbers of people we can test, not the method itself. If you want to challenge the established and well documented sensitivity/specificity numbers you need to dig out real facts and numbers.]]></description>
		<content:encoded><![CDATA[<p>Sergio. Your undocumented statement against a well established diagnostic molecular test is &#8220;&#8230;can be diagnosed exclusively with sophisticated semeiotics (who’s specificity/sensitivity is about 60%!)&#8221;. Your statement is wrong. Given that the samples are taken appropriately, our method (same as used by health agencies around the world) has a very high sensitivity 98-99 % or more, and a specificity of very close to 100 %. Thus, diagnosing this infection is currently not problematic at all, and any further improvements in diagnostics is going to be in the numbers of people we can test, not the method itself. If you want to challenge the established and well documented sensitivity/specificity numbers you need to dig out real facts and numbers.</p>
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		<title>By: Sergio Stagnaro</title>
		<link>http://biopinionated.com/2009/11/20/swine-flu-a-family-history/#comment-671</link>
		<dc:creator><![CDATA[Sergio Stagnaro]]></dc:creator>
		<pubDate>Wed, 25 Nov 2009 13:32:02 +0000</pubDate>
		<guid isPermaLink="false">http://biopinionated.com/?p=1921#comment-671</guid>
		<description><![CDATA[I read: &quot;We, gave our daughter Tamiflu®, since symptoms suggested possible SwineFlu infection&quot;. Horrible to say, according to Romans!The following Letter, accepted by The Lancet Editors (all documented) has been rejected by referees...
Please read and comment:
FLU Diagnosis and Differential Diagnosis between seasonal virus and A/H1N1.
Editors,
all around the world physicians are thinking erroneously that various types of flu, including A/H1N1, swine flu, can be diagnosed exclusively with sophisticated semeiotics (who’s specificity/sensitivity is about 60%!), certainly not applicable on very large scale. In addition, all antiviral drugs must be utilize in the first stage of disorder. In my opinion, this thought is not updated, since authors unfortunately ignore Quantum Biophysical Semeiotics (www.semeioticabiofisica.it). In fact, nowadays it is very difficult to know the real nature of an infectious disorder at both the bed-side and ER or hospital, as well as to recognize a lot of cases, not to speak of disorders recognizable by means of the academic, orthodox, physical semeiotics, as allows me to state a 53-year- long clinical experience. In fact, I am filled with wonder at reading that there are doctors who are sharing the uncertainty of the value of antibiotics for acute tonsillitis, pharyngitis, bronchitis in the form of written and verbal advice, although I do not know if these physicians are skill at performing the advancement in the field of physical examination (1). Interesting from diagnostic view-point, I underscore here the possibility of recognizing easily and quickly the “chronic” antibodies synthesis in the spleen during flu, as well as the spleen “small” antibody production, in case of Gram-negative bacteria (Esch.coli, HP, Clamidya, H. pyloris, a.s.o.), which play a pivotal role in bed-side diagnosis of virus or Gram- negative infections (1). Moreover, interestingly doctor can now a-day observes clinically, and in a “quantitative” way, the so-called Reticulo- Endothelial-System-Hyperfunction Syndrome (RESH), which parallels with ESR and Proteins Electrophoresis, but it is “more” sensitive and specific than both (2, 3, 7, 8). Certainly, most adults, and children, of course, with acute bronchitis who consult their general practitioner will receive antibiotics, although in many cases antibiotics do not modify the natural course of the disorder, at all. In my mind, the real problem is to recognize “clinically” both the nature of infectious disorder and the actual patient&#039;s defence , including antibody and PCR synthesis (in above- cited website): first, the “ethiological” , complete diagnose, starting from bedside recognizing all constitutions (4, 6) and, then, the proper therapy (8) . Nowadays, we can solve such as problem, and a lot of others, if physicians, Referees, peer-review&#039;s Editors, and particularly WHO Authorities are determined to be “open-minded”, farsighted, and free. 
Regarding differential diagnosis between seasonal flu virus and A/H1N1, a central role are played by parametric values of BALT-gastric aspecific reflex, informing about antibody synthesis. In seasonal flu, starting from the contagious, as well as immediately after vaccine injection, latency time lowers to 4-5 sec. (NN = lt. 6 sec.), and reflex intensity is 3 cm. (NN = 2 cm.) (1, 2). 
On the contrary, in case of swine flu, latency time is lowest, 2-3 sec, while reflex intensity is highest, i.e., 5 cm. In addition, even when gastro-entero-colitis is absent, antibody synthesis in the lever and intestinal lymph-nodules parallels that of BALTH.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Ed. Travel Factory SRL., Roma, 2004. www.travelfactory.it 
2) Stagnaro-Neri M., Stagnaro S., Appendicite. Min. Med. 87, 183, 1996[MEDLINE] 
3) Stagnaro S., Sindrome percusso-ascoltatoria di Iperfunzione del Sistema Reticolo-Istiocitario Min. Med. 74, 479, 1983 [MEDLINE]. 
4) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. 
5) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005. 
6) Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE] 
7) Stagnaro S., Singh RB. Influence Of Nutrition On Pre-metabolic Syndrome And Vascular Variability Syndrome. Editorial, The Open Nutrition Journal. Bentham Sci. Publish. In press.
8) Stagnaro Sergio. Quantum-Biophysical-Semeiotic Bedside Diagnosis of Flu, since its earliest stage. www.CMAJ.com, 29 October, 2009, http://www.cmaj.ca/cgi/eletters?lookup=by_date&amp;days=21#228652]]></description>
		<content:encoded><![CDATA[<p>I read: &#8220;We, gave our daughter Tamiflu®, since symptoms suggested possible SwineFlu infection&#8221;. Horrible to say, according to Romans!The following Letter, accepted by The Lancet Editors (all documented) has been rejected by referees&#8230;<br />
Please read and comment:<br />
FLU Diagnosis and Differential Diagnosis between seasonal virus and A/H1N1.<br />
Editors,<br />
all around the world physicians are thinking erroneously that various types of flu, including A/H1N1, swine flu, can be diagnosed exclusively with sophisticated semeiotics (who’s specificity/sensitivity is about 60%!), certainly not applicable on very large scale. In addition, all antiviral drugs must be utilize in the first stage of disorder. In my opinion, this thought is not updated, since authors unfortunately ignore Quantum Biophysical Semeiotics (www.semeioticabiofisica.it). In fact, nowadays it is very difficult to know the real nature of an infectious disorder at both the bed-side and ER or hospital, as well as to recognize a lot of cases, not to speak of disorders recognizable by means of the academic, orthodox, physical semeiotics, as allows me to state a 53-year- long clinical experience. In fact, I am filled with wonder at reading that there are doctors who are sharing the uncertainty of the value of antibiotics for acute tonsillitis, pharyngitis, bronchitis in the form of written and verbal advice, although I do not know if these physicians are skill at performing the advancement in the field of physical examination (1). Interesting from diagnostic view-point, I underscore here the possibility of recognizing easily and quickly the “chronic” antibodies synthesis in the spleen during flu, as well as the spleen “small” antibody production, in case of Gram-negative bacteria (Esch.coli, HP, Clamidya, H. pyloris, a.s.o.), which play a pivotal role in bed-side diagnosis of virus or Gram- negative infections (1). Moreover, interestingly doctor can now a-day observes clinically, and in a “quantitative” way, the so-called Reticulo- Endothelial-System-Hyperfunction Syndrome (RESH), which parallels with ESR and Proteins Electrophoresis, but it is “more” sensitive and specific than both (2, 3, 7, 8). Certainly, most adults, and children, of course, with acute bronchitis who consult their general practitioner will receive antibiotics, although in many cases antibiotics do not modify the natural course of the disorder, at all. In my mind, the real problem is to recognize “clinically” both the nature of infectious disorder and the actual patient&#8217;s defence , including antibody and PCR synthesis (in above- cited website): first, the “ethiological” , complete diagnose, starting from bedside recognizing all constitutions (4, 6) and, then, the proper therapy (8) . Nowadays, we can solve such as problem, and a lot of others, if physicians, Referees, peer-review&#8217;s Editors, and particularly WHO Authorities are determined to be “open-minded”, farsighted, and free.<br />
Regarding differential diagnosis between seasonal flu virus and A/H1N1, a central role are played by parametric values of BALT-gastric aspecific reflex, informing about antibody synthesis. In seasonal flu, starting from the contagious, as well as immediately after vaccine injection, latency time lowers to 4-5 sec. (NN = lt. 6 sec.), and reflex intensity is 3 cm. (NN = 2 cm.) (1, 2).<br />
On the contrary, in case of swine flu, latency time is lowest, 2-3 sec, while reflex intensity is highest, i.e., 5 cm. In addition, even when gastro-entero-colitis is absent, antibody synthesis in the lever and intestinal lymph-nodules parallels that of BALTH.<br />
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Ed. Travel Factory SRL., Roma, 2004. <a href="http://www.travelfactory.it" rel="nofollow">http://www.travelfactory.it</a><br />
2) Stagnaro-Neri M., Stagnaro S., Appendicite. Min. Med. 87, 183, 1996[MEDLINE]<br />
3) Stagnaro S., Sindrome percusso-ascoltatoria di Iperfunzione del Sistema Reticolo-Istiocitario Min. Med. 74, 479, 1983 [MEDLINE].<br />
4) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004.<br />
5) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005.<br />
6) Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]<br />
7) Stagnaro S., Singh RB. Influence Of Nutrition On Pre-metabolic Syndrome And Vascular Variability Syndrome. Editorial, The Open Nutrition Journal. Bentham Sci. Publish. In press.<br />
8) Stagnaro Sergio. Quantum-Biophysical-Semeiotic Bedside Diagnosis of Flu, since its earliest stage. <a href="http://www.CMAJ.com" rel="nofollow">http://www.CMAJ.com</a>, 29 October, 2009, <a href="http://www.cmaj.ca/cgi/eletters?lookup=by_date&#038;days=21#228652" rel="nofollow">http://www.cmaj.ca/cgi/eletters?lookup=by_date&#038;days=21#228652</a></p>
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