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	<title>BIOpinionated &#187; Alzheimer</title>
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		<title>BIOpinionated &#187; Alzheimer</title>
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		<title>Tests that make me sad (updated)</title>
		<link>http://biopinionated.com/2008/02/29/tests-that-make-me-sad-updated/</link>
		<comments>http://biopinionated.com/2008/02/29/tests-that-make-me-sad-updated/#comments</comments>
		<pubDate>Fri, 29 Feb 2008 10:46:40 +0000</pubDate>
		<dc:creator>sciphu</dc:creator>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[Alzheimer]]></category>
		<category><![CDATA[athletic performance]]></category>
		<category><![CDATA[BRCA1]]></category>
		<category><![CDATA[genetic testing]]></category>
		<category><![CDATA[slippery slope]]></category>

		<guid isPermaLink="false">http://sciphu.wordpress.com/?p=54</guid>
		<description><![CDATA[In a previous post (&#8220;Clarifying misuse of Science&#8220;) I expressed concerns over Prenatal testing for familial hypercholesterolemia. Now it seems I should have included two more (and in my mind, &#8211; more controversial) tests approved in the UK for preimplantation testing preceding IVF. These are tests for breast cancer (BRCA1) and early onset Alzheimer. Especially [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=biopinionated.com&#038;blog=2278731&#038;post=54&#038;subd=sciphu&#038;ref=&#038;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>In a previous post (&#8220;<a href="http://sciphu.wordpress.com/wp-admin/Clarifying%20Misuse%20of%20Science">Clarifying misuse of Science</a>&#8220;) I expressed concerns over <a href="http://www.timesonline.co.uk/tol/news/uk/science/article3054249.ece" target="_blank">Prenatal testing  for familial hypercholesterolemia</a>. Now it seems I should have included two more (and in my mind, &#8211; more controversial) tests approved in the UK for preimplantation testing preceding <a href="http://en.wikipedia.org/wiki/IVF">IVF</a>. These are tests for <a href="http://www.timesonline.co.uk/tol/news/uk/science/article2112659.ece">breast cancer</a> (BRCA1) and early onset <a href="http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2007/09/20/nivf120.xml">Alzheimer</a>.</p>
<p>Especially the case of  BRCA1 worries me. True, the prevention (<a href="http://en.wikipedia.org/wiki/Mastectomy">mastectomy</a>) is  a horrible ordeal for the patient, but is this sufficient grounds for excluding eggs for IVF ? Can&#8217;t you live a reasonably happy and normal life after such a procedure (see <a href="http://en.wikipedia.org/wiki/Breast_reconstruction">breast reconstruction</a>) ?</p>
<p>Why haven&#8217;t there been more fuzz around this ? Is everyone going to be using prestested eggs in IVF now ? And what are the limits on acceptable tests, will testing for <a href="http://www.gtg.com.au/HumanDNATesting/index.asp?menuid=070.110" target="_blank">athletic performance</a> become an exclusion criterion soon ?</p>
<p>I must have been naive to so strongly oppose the <a href="http://en.wikipedia.org/wiki/Slippery_slope">slippery slope</a> argument in genetic testing discussions up until now. I wish we could restrain ourselves a bit more, but fear that we can&#8217;t.</p>
<p>The solution is to come up with treatments for most of these conditions (although treating athletic performance may constitute a problem in terms of the number of people needing treatment as well as treatment alternatives&#8230;..).</p>
<p>Treatment alternatives need to appear soon if we&#8217;re to avoid the <a href="http://en.wikipedia.org/wiki/Brave_new_world">brave new world</a> future that critics of the genetics era have been promoting &#8230;..</p>
<p>The &#8220;find a cure&#8221; process however, is not going to be fast and in the 10-25 years to follow, those concerned couples that have the option of BRCA1 and Alzheimer testing will most likely not take the chance that a treatment will be found in time for their child to be cured&#8230;&#8230;.., &#8211; and opt for the safer pretested egg and IVF.</p>
<p>Seeing that the slope is becoming slippery I have decided not to argue for genetic testing any further, and if this trend continues, &#8211; argue against, at least until treatment options appear (the next 25? years) or a sensible limit for testing is drawn (right now, &#8211; please).</p>
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		<title>Tests that make me sad</title>
		<link>http://biopinionated.com/2008/01/07/tests-that-make-me-sad/</link>
		<comments>http://biopinionated.com/2008/01/07/tests-that-make-me-sad/#comments</comments>
		<pubDate>Mon, 07 Jan 2008 09:45:11 +0000</pubDate>
		<dc:creator>sciphu</dc:creator>
				<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[Alzheimer]]></category>
		<category><![CDATA[BRCA1]]></category>
		<category><![CDATA[genetic testing]]></category>
		<category><![CDATA[slippery slope]]></category>

		<guid isPermaLink="false">http://sciphu.wordpress.com/2008/01/07/tests-that-make-me-sad/</guid>
		<description><![CDATA[In a previous post (&#8220;Clarifying misuse of Science&#8220;) I expressed concerns over Prenatal testing for familial hypercholesterolemia. Now it seems I should have included two more (and in my mind, &#8211; more controversial) tests approved in the UK for preimplantation testing preceding IVF. These are tests for breast cancer (BRCA1) and early onset Alzheimer. I [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=biopinionated.com&#038;blog=2278731&#038;post=22&#038;subd=sciphu&#038;ref=&#038;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>In a previous post (&#8220;<a href="http://sciphu.wordpress.com/wp-admin/Clarifying%20Misuse%20of%20Science">Clarifying misuse of Science</a>&#8220;) I expressed concerns over <a href="http://www.timesonline.co.uk/tol/news/uk/science/article3054249.ece" target="_blank">Prenatal testing  for familial hypercholesterolemia</a>. Now it seems I should have included two more (and in my mind, &#8211; more controversial) tests approved in the UK for preimplantation testing preceding <a href="http://en.wikipedia.org/wiki/IVF">IVF</a>. These are tests for <a href="http://www.timesonline.co.uk/tol/news/uk/science/article2112659.ece">breast cancer</a> (BRCA1) and early onset <a href="http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2007/09/20/nivf120.xml">Alzheimer</a>.</p>
<p>I must have been naive to oppose the <a href="http://en.wikipedia.org/wiki/Slippery_slope">slippery slope</a> argument in genetic testing discussions up until now. I wish we could restrain ourselves a bit more, but fear that we can&#8217;t. Why haven&#8217;t there been more fuzz around this ? Is everyone going to switch to using prestested eggs in IVF now ?</p>
<p>A (tricky) solution is to come up with treatments for most of these conditions, &#8211; looks like that needs to happen fast if we&#8217;re to avoid the <a href="http://en.wikipedia.org/wiki/Brave_new_world">brave new world</a> future that critics of the genetics era have been promoting &#8230;..</p>
<p>The &#8220;find a cure&#8221; process of course, is not going to be fast and in the 10-25 years to follow, those concerned couples that have this option will most likely not take the chance that a treatment will be found in time for their child to be cured, and opt for the safer pretested egg and IVF.</p>
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